JWH 081 N-(4-hydroxypentyl) metabolite

Description

Buy JWH 081 N-(4-hydroxypentyl) metabolite
Metabolite is a primary phase I metabolite of JWH-081, a synthetic cannabinoid. JWH-081 and its metabolites are studied for their interaction with the endocannabinoid system and are of interest in toxicology and forensic analysis, especially in the context of designer drug detection.

Parent Compound: JWH-081

Full Name: (4-Methoxynaphthalen-1-yl)(1-pentylindol-3-yl)methanone

Class: Synthetic cannabinoid (1-naphthoylindole family)

Activity: Potent CB₁ receptor agonist (strong psychoactive effects)

Metabolite Identity and Formation

Name: JWH-081 N-(4-hydroxypentyl) metabolite

Chemical Nature: Phase I hydroxylation product

Structure: Hydroxyl group is introduced at the 4th carbon of the N-pentyl side chain

Enzyme Involvement: Primarily metabolized by cytochrome P450 enzymes (CYPs) in the liver

Hydroxylation increases polarity, aiding in renal excretion and forming the basis for urine drug testing.

Pharmacology

While the metabolite itself is less active than the parent compound (JWH-081), some hydroxylated metabolites of synthetic cannabinoids may retain partial agonist activity at cannabinoid receptors.

CB₁ Activity: Likely reduced compared to JWH-081

CB₂ Activity: Limited data available

May contribute to overall pharmacodynamic profile in users

Detection in Biological Samples

Detection of this metabolite is critical for forensic and clinical toxicology, particularly where the parent drug has already been metabolized.

Common Analytical Methods:
LC-MS/MS (Liquid Chromatography–Tandem Mass Spectrometry)

GC-MS (Gas Chromatography–Mass Spectrometry) after derivatization

High-resolution mass spectrometry (HRMS) for confirmation

Biological Matrices:
Urine: Primary matrix for metabolite detection

Blood and plasma: Parent compound usually dominates

Hair (occasionally): For retrospective analysis of chronic use

Forensic Significance

The presence of JWH-081 N-(4-hydroxypentyl) metabolite in a sample confirms recent exposure to JWH-081, even if the parent compound is no longer detectable.

Useful in postmortem toxicology

Evidence of drug use in workplace, sports, or legal cases

Helps distinguish specific synthetic cannabinoid intake, especially among similar compounds

Legal and Regulatory Implications

While metabolites themselves are not directly scheduled, detection of this metabolite often implies use of JWH-081, which is:

Controlled in many countries as part of synthetic cannabinoid legislation

May fall under analogue drug laws where not explicitly listed

Regulated in the U.S. under Schedule I (DEA)

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