ADB-FUBINACA is a synthetic cannabinoid,
structurally derived from indazole-3-carboxamides. Originally developed by Pfizer for potential therapeutic use in pain management, ADB-FUBINACA was never approved for medical use. It later appeared on the illicit drug market as a highly potent component in synthetic cannabis products like “Spice” or “K2.” It is considered one of the most powerful and dangerous synthetic cannabinoids ever detected in recreational drug supplies for ADB-FUBINACA, ADB-FUB.
Chemical IdentityIUPAC Name: N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indazole-3-carboxamideCommon Names: ADB-FUBINACA, ADB-FUBMolecular Formula: C₂₁H₂₃FN₄O₂Molecular Weight: 382.43 g/molChemical Class: Indazole-based synthetic cannabinoidPhysical Form: White or off-white crystalline powderCAS Number: 1185282-01-2Structurally, it belongs to the family of indazole-3-carboxamides with a fluorobenzyl substitution and a dimethylbutanamide group, which significantly increases its binding affinity and potency.
Pharmacology and Mechanism of ActionADB-FUBINACA acts as a full agonist at both CB₁ and CB₂ receptors of the endocannabinoid system. Its binding affinity to CB₁ is exceptionally high (with Ki values in the low nanomolar range), making it far more potent than Δ9-THC (the primary psychoactive compound in cannabis).Effects typically observed include:Intense psychoactive responseRapid onset of sedation and euphoriaAltered perception and moodAnxiety, confusion, or paranoiaLoss of motor controlPotency comparison: ADB-FUBINACA is estimated to be 50–100 times more potent than THC, with effective doses in the microgram range, making precise dosage extremely difficult and increasing the risk of overdose.
Toxicology and Adverse EffectsDue to its high potency and full agonist action, ADB-FUBINACA has been linked to serious and sometimes fatal toxic reactions. Cases reported in emergency rooms and forensic toxicology labs include:<
Given its significant public health risk, ADB-FUBINACA has been banned in many countries:United States: Schedule I controlled substanceUnited Kingdom: Class B under the Misuse of Drugs ActCanada: Listed as a Schedule II synthetic cannabinoidEU Member States: Controlled individually or under blanket NPS regulationsAustralia & New Zealand: Prohibited as a synthetic cannabinoid analogueIts synthesis, sale, or possession is illegal in most jurisdictions, except for licensed forensic or scientific research.
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