AB-CHMINACA (N-[1-amino-3-methyl-1-oxobutan-2-yl]-1-(cyclohexylmethyl)-1H-indazole-3-carboxamide) Is a potent indazole-based synthetic cannabinoid originally developed by Pfizer. In recreational markets, it is frequently sold as a spray-on herbal mixture ("Spice", "K2", etc.) where the compound is dissolved in solvent and applied to plant material to mimic natural cannabis. These formulations are highly inconsistent in dose, leading to unpredictable and dangerous outcomes.
Chemical Identity and Structure
IUPAC Name: N-[1-amino-3-methyl-1-oxobutan-2-yl]-1-(cyclohexylmethyl)-1H-indazole-3-carboxamide
Common Name: AB-CHMINACA
Chemical Class: Synthetic cannabinoid (indazole carboxamide)
Molecular Formula: C₂₀H₂₈N₄O₂
Molecular Weight: 356.46 g/mol
Form Used in Market: Dissolved in acetone or ethanol, then sprayed onto inert herbs (e.g., marshmallow leaf)
Pharmacology and Mechanism of Action
AB-CHMINACA is a full agonist at:
CB₁ Receptors (CNS): Produces intense psychoactive effects; far stronger than THC
CB₂ Receptors (Peripheral immune system): Less psychoactive but potentially immunomodulatory
Binding affinity:
CB₁ Ki ≈ 0.78 nM (significantly more potent than THC)
Due to high potency and full agonism, AB-CHMINACA lacks the self-limiting ceiling of THC, leading to overactivation of cannabinoid receptors and associated toxicity.
Toxicity and Adverse Effects (Especially in Spray Form)
The spray format is highly dangerous due to uneven application and hotspots (over-concentrated patches on herbs). Users may unknowingly inhale toxic or overdose-level doses.
Common Adverse Effects:
Neurological: Blackouts, seizures, muscle rigidity, tremors
Cardiovascular: Tachycardia, hypertension, cardiac arrest
Psychiatric: Aggression, hallucinations, acute psychosis
Physical: Vomiting, respiratory depression, unconsciousness
Numerous hospitalizations and deaths have been linked to AB-CHMINACA-laced products.
Legal Status and Control
Due to its dangers and widespread misuse, AB-CHMINACA is banned in most regions:
United States: Schedule I controlled substance (since 2015)
European Union: Controlled under synthetic cannabinoid legislation
UK, Australia, Canada: Banned under general psychoactive substances laws
UNODC: Recommended for international scheduling in response to fatalities
Enforcement is challenging due to analog switching and isomer marketing.
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