2-NMC (2-(methylamino)-1-(4-methylphenyl)propan-1-one)

Is a synthetic stimulant belonging to the cathinone class, structurally similar to mephedrone and other β-keto amphetamines. Originally synthesized for pharmacological research, 2-NMC has surfaced on the novel psychoactive substances (NPS) market as a “legal high.” Typically encountered in crystalline or powdered form, it is used recreationally for its stimulant and empathogenic effects.

Chemical Identity and Structure

IUPAC Name: 2-(methylamino)-1-(4-methylphenyl)propan-1-one
Common Name: 2-NMC Chemical Class: Synthetic cathinone (β-keto amphetamine derivative) Molecular Formula: C₁₁H₁₅NO Molecular Weight: 177.24 g/mol Physical Form: White or off-white crystalline solid The 4-methyl substitution on the phenyl ring is a hallmark feature, closely resembling 4-MMC (mephedrone). The methylamino group adds stimulant potential via interaction with monoamine transporters.
Pharmacology and Mechanism of Action

Like other cathinones, 2-NMC is believed to function as a dopamine–norepinephrine reuptake inhibitor (DNRI) and monoamine releasing agent:
DAT Blockade and Release: Increases synaptic dopamine → euphoria, alertness, reward-seeking NET Blockade and Release: Boosts norepinephrine → physical stimulation, increased heart rate Potential SERT Activity: Mild serotonin modulation, may contribute to empathogenic effects User reports often compare 2-NMC’s effects to mephedrone, though with slightly reduced potency. Onset is rapid via insufflation or inhalation, with effects lasting 2–4 hours.
Toxicity and Adverse Effects

Due to its limited clinical evaluation, 2-NMC’s toxicity profile is extrapolated from similar cathinones:
Cardiovascular: Tachycardia, vasoconstriction, palpitations Neurological: Tremors, restlessness, muscle tension, insomnia Psychiatric: Anxiety, paranoia, impulsive redosing, hallucinations at high doses Other Risks: Dehydration, hyperthermia, jaw clenching (bruxism) Overdosing or repeated use can lead to serotonin syndrome, cardiac events, or seizures. Combination with other stimulants or alcohol elevates risks significantly.
Legal Status and Control

2-NMC is controlled or monitored under various jurisdictions as an analogue or cathinone derivative:
United States: May be prosecuted under the Federal Analogue Act United Kingdom: Covered under the Psychoactive Substances Act 2016 European Union: Many countries ban it under cathinone-specific or generic legislation Canada & Australia: Falls under analogue scheduling of controlled substances Regulatory agencies continue to update control lists in response to the dynamic and adaptive NPS market.
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