5F-PV8 is a synthetic stimulant

And a structural derivative of α-pyrrolidinovalerophenone (α-PVP), commonly referred to as a synthetic cathinone or “bath salt” compound. It is part of the pyrrolidinophenone class of designer drugs, with a fluorinated alkyl chain that increases its lipophilicity and may affect receptor binding dynamics. Though limited data exist due to its status as a novel psychoactive substance (NPS), 5F-PV8 has been identified in forensic cases and seized samples, indicating its role in the illicit stimulant market.

Chemical Identity and Structure

IUPAC Name: 1-(5-fluoropentyl)-α-pyrrolidinovalerophenone
Common Name: 5F-PV8 Chemical Class: Synthetic cathinone / pyrrolidinophenone derivative Molecular Formula: C₁₇H₂₄FNO Molecular Weight: ~277.38 g/mol CAS Number: Not universally registered; varies by regional classification Physical Appearance: White to off-white crystalline powder Structurally, 5F-PV8 shares features with other synthetic stimulants like α-PVP, MDPV, and α-PHP, with the key difference being the presence of a fluorinated pentyl side chain, which can significantly alter pharmacokinetics and potency.
Pharmacology and Mechanism of Action

Though not extensively studied in controlled laboratory environments, 5F-PV8 is presumed to act as a dopamine and norepinephrine reuptake inhibitor (DNRI), similar to its non-fluorinated analogues. This mechanism increases synaptic concentrations of key monoamines, leading to stimulant-like effects such as:
Increased alertness and energy Elevated mood or euphoria Heightened focus or stimulation Appetite suppression Insomnia Due to the fluorine substitution, 5F-PV8 may cross the blood-brain barrier more efficiently, potentially amplifying both psychoactive effects and toxicity.
Toxicological Profile and Adverse Effects

As with most synthetic cathinones, 5F-PV8 carries a high potential for abuse, dependence, and acute toxicity. Reported effects in clinical and forensic contexts include:
Neurological: anxiety, paranoia, agitation, hallucinations, seizures Cardiovascular: tachycardia, hypertension, arrhythmias Psychiatric: psychosis-like behavior, suicidal ideation Physical: dehydration, bruxism (jaw clenching), hyperthermia The dose-response curve is often steep, meaning small increases in dose can lead to disproportionately large increases in effects or side effects. In some cases, prolonged use may result in dopaminergic neurotoxicity and cardiovascular damage.
Legal Status and Regulation

Due to its classification as a synthetic cathinone, 5F-PV8 is subject to legal control in many regions, either by name or through analogue legislation.
United States: Likely treated as a Schedule I analogue of α-PVP United Kingdom: Controlled under the Psychoactive Substances Act (PSA) Germany: Regulated under the New Psychoactive Substances Act (NpSG) China, Australia, and Canada: Often banned by structural similarity laws The compound's emergence is part of a broader trend of slight molecular modifications designed to evade legislation while maintaining psychoactivity.
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