AB-CHMINACA,
A highly potent indazole-based synthetic cannabinoid, is frequently encountered in liquid/solution form, where it is dissolved in solvents such as acetone, ethanol, or propylene glycol for various applications. The solution is primarily used for soaking herbal material, vaping in e-liquid mixtures, or impregnating paper (e.g., in prisons) — increasing the risk of overdose and undetectable administration.
Chemical Identity and Structure
IUPAC Name: N-[1-amino-3-methyl-1-oxobutan-2-yl]-1-(cyclohexylmethyl)-1H-indazole-3-carboxamide
Common Name: AB-CHMINACA
Chemical Class: Indazole-3-carboxamide synthetic cannabinoid
Molecular Formula: C₂₀H₂₈N₄O₂
Molecular Weight: 356.46 g/mol
Formulation (Solution): Often 10–100 mg/mL dissolved in organic solvent (e.g., acetone, PG/VG, ethanol)
Use and Administration in Solution Form
The solution format enables AB-CHMINACA to be:/br>
Sprayed onto herbal substrates (Spice/K2 products)
Mixed into e-liquids for vaping
Soaked into blotting paper or textiles (commonly smuggled into prisons)
Dropped onto tobacco/cannabis before smoking
This form increases concealability and reduces control over dosage, making it extremely high-risk.
Pharmacology and Mechanism of Action
As with its powder form, AB-CHMINACA solution acts as a full agonist at cannabinoid receptors, with very high potency:
CB₁ Receptor: Induces extreme psychoactive effects (e.g., confusion, catalepsy, euphoria, psychosis)
CB₂ Receptor: Less central involvement, may influence immune and peripheral effects
Potency Estimate: Up to 100x stronger than THC
EC₅₀ and Ki values: Sub-nanomolar range — indicating high binding and activation strength
Even microgram-level doses may result in serious intoxication, especially if the solution is not evenly distributed.
Toxicity and Health Risks
Solution-based AB-CHMINACA use is linked to unpredictable and life-threatening reactions due to inconsistent administration routes (vaping, soaking, dabbing).
Key Adverse Effects:
Neurological: Seizures, stupor, loss of consciousness
Cardiovascular: Hypertension, arrhythmias, cardiac arrest
Respiratory: Suppression, hypoxia (especially with vaped forms)
Psychiatric: Hallucinations, aggression, acute psychosis
Fatal Outcomes: Documented in forensic toxicology reports worldwide
Solution forms are more dangerous than herbal forms due to ease of accidental overdose and lack of visual cues for dose estimation.
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