4-CPrC (1-(4-cyclopropylphenyl)-2-(methylamino)propan-1-one)

Is a novel synthetic cathinone, emerging as a designer stimulant in the novel psychoactive substance (NPS) market. Featuring a para-cyclopropyl substitution on its phenyl ring, 4-CPrC modifies the traditional cathinone scaffold to potentially alter lipophilicity, blood–brain barrier penetration, and transporter binding. Although initially synthesized for pharmacological exploration, it has been diverted into unregulated channels and is typically encountered as a fine crystalline powder.

Chemical Identity and Structure

IUPAC Name: 1-(4-cyclopropylphenyl)-2-(methylamino)propan-1-one
Common Name: 4-CPrC Chemical Class: Synthetic cathinone (β-keto amphetamine derivative) Molecular Formula: C₁₃H₁₇NO Molecular Weight: 203.28 g/mol Physical Form: White to off-white crystalline solid The para-cyclopropyl moiety distinguishes 4-CPrC from other cathinones, replacing typical alkyl or halogen substituents with a strained three-membered ring, which may influence its metabolic stability and central nervous system activity.
Pharmacology and Mechanism of Action

4-CPrC is presumed to act primarily as a dopamine–norepinephrine reuptake inhibitor (DNRI):
Dopamine transporter (DAT) blockade: Elevates synaptic dopamine, driving euphoria, reinforcement, and psychomotor activation Norepinephrine transporter (NET) blockade: Raises norepinephrine levels, increasing alertness, cardiovascular stimulation, and arousal User reports indicate rapid onset (especially if insufflated or vaporized), with effects such as heightened energy, enhanced sociability, and appetite suppression. The cyclopropyl group may prolong receptor interaction, potentially extending the stimulant effects compared to unsubstituted cathinones.
Legal Status and Control

As a designer cathinone, 4-CPrC may fall under analogue or generic stimulant legislation:
United States: Potentially prosecutable under the Federal Analogue Act if intended for human consumption United Kingdom & EU: Likely controlled under blanket bans on cathinones and psychoactive substances Australia & Canada: Covered by broad “research chemical” or analogue scheduling Possession, distribution, or manufacture without explicit authorization can result in criminal penalties, though enforcement is challenged by rapid structural innovation.
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