2-NMC (2-(methylamino)-1-(4-methylphenyl)propan-1-one) Is a synthetic stimulant belonging to the cathinone class, structurally similar to mephedrone and other β-keto amphetamines. Originally synthesized for pharmacological research, 2-NMC has surfaced on the novel psychoactive substances (NPS) market as a “legal high.” Typically encountered in crystalline or powdered form, it is used recreationally for its stimulant and empathogenic effects.
Chemical Identity and Structure
IUPAC Name: 2-(methylamino)-1-(4-methylphenyl)propan-1-oneCommon Name: 2-NMCChemical Class: Synthetic cathinone (β-keto amphetamine derivative)Molecular Formula: C₁₁H₁₅NOMolecular Weight: 177.24 g/molPhysical Form: White or off-white crystalline solidThe 4-methyl substitution on the phenyl ring is a hallmark feature, closely resembling 4-MMC (mephedrone). The methylamino group adds stimulant potential via interaction with monoamine transporters.
Pharmacology and Mechanism of Action
Like other cathinones, 2-NMC is believed to function as a dopamine–norepinephrine reuptake inhibitor (DNRI) and monoamine releasing agent:DAT Blockade and Release: Increases synaptic dopamine → euphoria, alertness, reward-seekingNET Blockade and Release: Boosts norepinephrine → physical stimulation, increased heart ratePotential SERT Activity: Mild serotonin modulation, may contribute to empathogenic effectsUser reports often compare 2-NMC’s effects to mephedrone, though with slightly reduced potency. Onset is rapid via insufflation or inhalation, with effects lasting 2–4 hours.
Toxicity and Adverse Effects
Due to its limited clinical evaluation, 2-NMC’s toxicity profile is extrapolated from similar cathinones:Cardiovascular: Tachycardia, vasoconstriction, palpitationsNeurological: Tremors, restlessness, muscle tension, insomniaPsychiatric: Anxiety, paranoia, impulsive redosing, hallucinations at high dosesOther Risks: Dehydration, hyperthermia, jaw clenching (bruxism)Overdosing or repeated use can lead to serotonin syndrome, cardiac events, or seizures. Combination with other stimulants or alcohol elevates risks significantly.
Legal Status and Control
2-NMC is controlled or monitored under various jurisdictions as an analogue or cathinone derivative:United States: May be prosecuted under the Federal Analogue ActUnited Kingdom: Covered under the Psychoactive Substances Act 2016European Union: Many countries ban it under cathinone-specific or generic legislationCanada & Australia: Falls under analogue scheduling of controlled substancesRegulatory agencies continue to update control lists in response to the dynamic and adaptive NPS market.
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