AMB-FUBINACA is a highly potent synthetic cannabinoid
Tthat has emerged as one of the most dangerous and frequently encountered novel psychoactive substances (NPS) in recent years. Originally developed by the pharmaceutical industry for research purposes, this compound gained infamy after being associated with mass overdose incidents and numerous fatalities across the United States, particularly in New York City.
Chemical Identity
IUPAC Name: Methyl (1-(4-fluorobenzyl)-1H-indazole-3-carbonyl)-L-valinate
Common Names: AMB-FUBINACA, FUB-AMB
Molecular Formula: C₂₀H₂₈FN₃O₃
Molecular Weight: 377.46 g/mol
Chemical Class: Indazole-based synthetic cannabinoid
Physical Form: White or off-white crystalline powder
AMB-FUBINACA is a derivative of the indazole-3-carboxamide class, similar to other synthetic cannabinoids like AB-FUBINACA and 5F-ADB, but with structural substitutions that dramatically increase its receptor binding affinity.
Pharmacodynamics and Mechanism of Action
AMB-FUBINACA acts as a full agonist at cannabinoid receptors CB₁ and CB₂, unlike natural cannabinoids such as THC, which are partial agonists. The result is a more intense and longer-lasting activation of the endocannabinoid system.
Key pharmacological characteristics:
Extremely high binding affinity at CB₁ (in the low nanomolar range)
Causes rapid-onset psychoactive effects
50–100 times more potent than Δ9-THC
Short duration of action, but strong peak effects
Users often experience:
Intense sedation
Confusion and disorientation
Auditory or visual hallucinations
Catatonia or loss of motor control
Because of its high potency, even microgram-level doses can trigger severe or fatal outcomes.
Toxicity and Public Health Risk
AMB-FUBINACA is associated with an exceptionally high rate of toxicity. Unlike THC, which has a relatively safe therapeutic window, synthetic cannabinoids like AMB-FUBINACA can cause acute and unpredictable reactions, even at low doses..
Reported toxic effects include:
Cardiac arrhythmias and chest pain
Seizures and convulsions
Respiratory depression
Aggression and psychosis
Muscle rigidity or breakdown (rhabdomyolysis)
Renal failure
Sudden loss of consciousness or death
In 2016–2018, dozens of people collapsed or died after using products containing AMB-FUBINACA in areas like Brooklyn, New York. These incidents were referred to in the media as “zombie outbreaks” due to the drug’s catatonic effects.
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