PV-8 (also known as α-Pyrrolidinoheptiophenone or α-PHP)

Is a synthetic cathinone and a designer stimulant that emerged in the novel psychoactive substances (NPS) market. As a structural analog of MDPV and α-PVP, PV-8 has gained attention due to its potent stimulant effects and abuse potential. It is often encountered as a crystalline powder or crystal form, referred to in underground markets as PV-8 Crystal.

Chemical Identity and Structure

IUPAC Name: 1-Phenyl-2-(pyrrolidin-1-yl)heptan-1-one
Common Name: PV-8, α-PHP Chemical Class: Synthetic cathinone (pyrrolidinophenone family) Molecular Formula: C₁₇H₂₅NO Molecular Weight: 259.39 g/mol Physical Form: White to off-white crystalline powder 💡 Structural Note: PV-8 differs from α-PVP by having a heptyl (7-carbon) side chain instead of a pentyl (5-carbon) one, increasing lipophilicity, which may influence duration of action and central nervous system (CNS) penetration.
Pharmacology and Mechanism of Action

PV-8 is believed to function primarily as a dopamine-norepinephrine reuptake inhibitor (DNRI):
DAT Inhibition: Increases dopamine → euphoria, stimulation, and addictive potential NET Inhibition: Increases norepinephrine → alertness, increased heart rate, and arousal Although direct pharmacological studies are limited, user reports and animal studies suggest strong stimulant properties, comparable to MDPV and α-PVP.
Toxicity and Adverse Effects

Like other synthetic cathinones, PV-8 carries significant health risks, especially when used at high doses or via inhalation routes:
Acute Effects: Increased energy and sociability Euphoria, talkativeness Appetite suppression Increased heart rate and blood pressure Adverse Reactions: Cardiovascular: Tachycardia, hypertension, chest pain Neurological: Agitation, tremors, seizures Psychiatric: Paranoia, hallucinations, panic attacks, psychosis Compulsive redosing: “Binging” behavior reported Dependence: High risk of psychological addiction PV-8 has a narrow therapeutic window, meaning small increases in dose can cause severe toxicity or overdose.
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