Pentylone (often referred to as bk-MBDP or β-keto-Methylbenzodioxolylpentanamine)

Is a synthetic cathinone and emerging psychoactive substance (EPS) that belongs to the bath salt family of stimulants. Commonly found in crystalline form, it has gained attention in both recreational and forensic contexts for its stimulant and empathogenic properties, somewhat similar to MDMA and methylone.

Chemical Identity and Structure

IUPAC Name: 1-(1,3-benzodioxol-5-yl)-2-(methylamino)pentan-1-one
Common Name: Pentylone Synonyms: βk-MBDP, β-keto-MBDP, bk-Pentylone Molecular Formula: C₁₄H₁₉NO₃ Molecular Weight: 249.31 g/mol Physical Form: White to off-white crystalline solid or powder 💡 Structural Note: Pentylone is structurally related to methylone, differing by having a longer side chain (pentyl instead of ethyl), which may affect its potency, duration, and lipid solubility.
Pharmacology and Mechanism of Action

Pentylone acts primarily as a monoamine transporter inhibitor and releaser, impacting:
Dopamine Transporter (DAT): Increases dopamine → stimulation, euphoria Serotonin Transporter (SERT): Increases serotonin → mood elevation, empathy Norepinephrine Transporter (NET): Increases norepinephrine → alertness, cardiovascular stimulation Its pharmacological profile resembles MDMA + amphetamine, although less entactogenic and more stimulating at high doses.
Toxicity and Adverse Effects

Although Pentylone is sold under the guise of a “research chemical,” its safety is poorly studied in humans. Based on similar compounds, reported risks include:
Short-Term Effects: Increased energy and sociability Elevated mood Mild euphoria Suppressed appetite Adverse Reactions: Cardiovascular: Elevated heart rate, blood pressure, palpitations Neurological: Headache, agitation, tremors Psychiatric: Anxiety, paranoia, insomnia, panic Physical: Jaw clenching, dehydration, muscle cramps High doses or prolonged use may lead to hyperthermia, serotonin syndrome, or cardiac complications.
Legal Status

Due to its similarity to other synthetic cathinones, Pentylone is increasingly regulated:
Country Legal Status United States Schedule I (via Federal Analogue Act) United Kingdom Class B under the Misuse of Drugs Act EU Nations Controlled under national psychoactive substance laws Australia Banned under cathinone analog laws Canada Schedule I substance if intended for human use
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