Methamphetamine (commonly known as "meth," "crystal," or "ice") Is a potent central nervous system stimulant with high potential for abuse, addiction, and neurotoxicity. Although it has limited therapeutic use in some countries, it is widely misused in crystalline form for its intense euphoric effects and stimulant properties.
C
hemical Identity and Properties
IUPAC Name: (S)-N-methyl-1-phenylpropan-2-amine
Common Names: Meth, Crystal Meth, Ice, Tina, Shabu
Chemical Class: Phenethylamine; amphetamine derivative
Molecular Formula: C₁₀H₁₅N
Molecular Weight: 149.24 g/mol
Physical Form: Transparent, colorless to white crystals ("crystal meth") or powder
Solubility: Highly soluble in water and alcohol
Routes of Use: Smoking, injection, snorting, oral ingestion
Pharmacology and Mechanism of Action
Methamphetamine acts primarily as a powerful dopamine and norepinephrine releaser, while also affecting serotonin:
Increases dopamine release → intense euphoria, motivation, and reinforcement
Elevates norepinephrine levels → alertness, increased heart rate and blood pressure
Long half-life (~10–12 hours) → prolonged stimulation compared to cocaine
Mechanism of Action:
Enters neurons via monoamine transporters
Reverses dopamine transporter (DAT), causing massive dopamine efflux
Inhibits MAO (monoamine oxidase) enzymes, further boosting neurotransmitter levels
Toxicity and Health Risks
Methamphetamine is highly neurotoxic and physically damaging:
Acute Effects:
Tachycardia, hypertension, chest pain
Anxiety, paranoia, hallucinations
Hyperthermia and seizures (especially at high doses)
Risk of overdose → stroke, heart attack, sudden death
Chronic Effects:
Severe dental decay (“meth mouth”)
Skin sores from picking
Malnutrition
Depression and anhedonia after withdrawal
Long-term brain damage, especially to dopaminergic neurons
Psychiatric Effects:
Meth-induced psychosis (paranoia, delusions)
Aggression, violent behavior
Obsessive-compulsive tendencies
Therapeutic Use and Regulation
Rarely prescribed for ADHD or obesity (under strict medical supervision)
Trade name: Desoxyn (in the U.S.)
Medical doses are much lower than recreational ones
Regulatory Status:
United States: Schedule II (under Controlled Substances Act)
UN: Listed in Schedule II of the Convention on Psychotropic Substances
Illegal without prescription in nearly all countries
Illicit Manufacturing and Purity
Illicit meth is typically synthesized via:
Reductive amination of ephedrine or pseudoephedrine
Nagai or Birch methods (using chemicals like red phosphorus, iodine, lithium)
Street meth ("crystal") may contain:
Contaminants (e.g., solvents, heavy metals)
Cutting agents (e.g., caffeine, sugars)
Variability in purity and toxicity
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