Buy JWH 081 N-(4-hydroxypentyl) metabolite
Metabolite is a primary phase I metabolite of JWH-081, a
synthetic cannabinoid. JWH-081 and its metabolites are studied for their interaction with the endocannabinoid system and are of interest in toxicology and forensic analysis, especially in the context of designer drug detection.
Parent Compound: JWH-081Full Name: (4-Methoxynaphthalen-1-yl)(1-pentylindol-3-yl)methanoneClass: Synthetic cannabinoid (1-naphthoylindole family)Activity: Potent CB₁ receptor agonist (strong psychoactive effects)
Metabolite Identity and FormationName: JWH-081 N-(4-hydroxypentyl) metaboliteChemical Nature: Phase I hydroxylation productStructure: Hydroxyl group is introduced at the 4th carbon of the N-pentyl side chainEnzyme Involvement: Primarily metabolized by cytochrome P450 enzymes (CYPs) in the liverHydroxylation increases polarity, aiding in renal excretion and forming the basis for urine drug testing.
PharmacologyWhile the metabolite itself is less active than the parent compound (JWH-081), some hydroxylated metabolites of synthetic cannabinoids may retain partial agonist activity at cannabinoid receptors.CB₁ Activity: Likely reduced compared to JWH-081CB₂ Activity: Limited data availableMay contribute to overall pharmacodynamic profile in users
Detection in Biological SamplesDetection of this metabolite is critical for forensic and clinical toxicology, particularly where the parent drug has already been metabolized.Common Analytical Methods:
LC-MS/MS (Liquid Chromatography–Tandem Mass Spectrometry)GC-MS (Gas Chromatography–Mass Spectrometry) after derivatizationHigh-resolution mass spectrometry (HRMS) for confirmationBiological Matrices:
Urine: Primary matrix for metabolite detectionBlood and plasma: Parent compound usually dominatesHair (occasionally): For retrospective analysis of chronic use
Forensic SignificanceThe presence of JWH-081 N-(4-hydroxypentyl) metabolite in a sample confirms recent exposure to JWH-081, even if the parent compound is no longer detectable.Useful in postmortem toxicologyEvidence of drug use in workplace, sports, or legal casesHelps distinguish specific synthetic cannabinoid intake, especially among similar compounds
Legal and Regulatory ImplicationsWhile metabolites themselves are not directly scheduled, detection of this metabolite often implies use of JWH-081, which is:Controlled in many countries as part of synthetic cannabinoid legislationMay fall under analogue drug laws where not explicitly listedRegulated in the U.S. under Schedule I (DEA)How to buy JWH 081 N-(4-hydroxypentyl) metabolite on line?purchase from medlinepharam is easy and safe. without a doubt follow those steps: purchase our internet site - discover the JWH 081 N-(4-hydroxypentyl) metabolite and pick the desired amount. upload to Cart - click on "Order Now" and go to the checkout. comfy payment - pick out one among several reliable bills alternatives. fast transport - we immediately technique your order and discreetly send it to your privacy.
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