JWH-018

Is a first-generation synthetic cannabinoid developed for scientific research into the endocannabinoid system, but it later emerged as a key active compound in “Spice,” “K2,” and other synthetic cannabis products. It mimics the effects of THC but binds more strongly to cannabinoid receptors, resulting in intense and unpredictable psychoactive effects.

Chemical Identity and Properties

Full Name: (Naphthalen-1-yl)(1-pentyl-1H-indol-3-yl)methanone
Common Names: JWH-018, Spice, K2 compound Chemical Class: Synthetic cannabinoid (indole-based) Molecular Formula: C₂₄H₂₃NO Molecular Weight: 341.45 g/mol Appearance: Off-white powder or oily residue; commonly sprayed onto plant material Solubility: Lipophilic (fat-soluble); dissolves in organic solvents
Pharmacology and Mechanism of Action

JWH-018 is a potent full agonist at CB₁ and CB₂ cannabinoid receptors:
CB₁ Receptor (brain): Mediates psychoactive effects like altered mood, perception, and motor control CB₂ Receptor (immune system): Modulates inflammation and immune responses Binding affinity at CB₁: ~5x higher than THC (Δ⁹-tetrahydrocannabinol)
Mechanism of Action:

Activates cannabinoid receptors, producing effects similar to THC Bypasses the natural modulation found with THC (which is only a partial agonist), leading to overstimulation and toxicity

Effects and User Reports

Synthetic cannabinoids like JWH-018 often have stronger and riskier effects than natural cannabis:
Desired Effects: Euphoria Relaxation Altered sensory perception Intense psychoactive "high" Adverse Effects: Anxiety, panic, agitation Rapid heartbeat, hypertension Hallucinations, paranoia Seizures, confusion, psychosis Vomiting and loss of consciousness Onset is rapid (minutes), and effects may last 1–3 hours depending on dose and route.
Toxicity and Health Risks

JWH-018 is associated with numerous health emergencies and hospitalizations, particularly due to:
Unpredictable potency Overdose risk (especially in sprayed plant products with uneven distribution) Neurotoxicity and psychological disturbances Toxicological Concerns: Agitation, delirium, aggression Kidney damage (reported in synthetic cannabinoid users) Potential cardiovascular events (tachycardia, arrhythmias) Dependence, tolerance, and withdrawal symptoms
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