5F-MN24 (5-fluoro-N-methyl-1-(naphthalen-1-yl)propan-2-amine) Is a synthetic cannabinoid belonging to the indole-3-carboxamide family, designed to probe the endocannabinoid system in laboratory settings. More recently, it has appeared as an illicit research chemical and in herbal smoking mixtures, prized by clandestine manufacturers for its potent CB₁ receptor activation and evasion of early scheduling efforts. Its novel structure and high efficacy raise serious concerns among toxicologists and regulatory bodies.
Chemical Identity and Structure
IUPAC Name: N-methyl-1-(naphthalen-1-yl)-2-(5-fluoro-1H-indol-3-yl)propan-1-amineCommon Name: 5F-MN24Chemical Class: Indole-3-carboxamide synthetic cannabinoidMolecular Formula: C₂₂H₂₃FN₂OMolecular Weight: 354.43 g/molPhysical Form: White to off-white crystalline powder5F-MN24 unites a fluorinated pentyl side chain on the indole core with a naphthyl propanamine substituent, increasing lipophilicity and receptor affinity compared to simpler analogues.
Pharmacology and Mechanism of Action
5F-MN24 functions as a full agonist at both CB₁ and CB₂ receptors:Receptor Affinity: Low-nanomolar Ki at CB₁, indicating high potencyOnset: Rapid (minutes when inhaled or vaporized)Duration: 2–5 hours, with peak effects in the first 60–90 minutesActivation of CB₁ receptors leads to:Intense euphoria and relaxationAltered perception of time, space, and sensory inputSedation or catalepsy at higher dosesImpaired motor coordination and cognitive functionUnlike THC’s partial agonism, 5F-MN24’s full agonist profile can produce far more pronounced and unpredictable psychoactive responses.
Toxicity and Adverse Effects
Because of its full-agonist nature and narrow therapeutic index, 5F-MN24 poses significant health risks:Neurological: agitation, anxiety, paranoia, hallucinations, seizuresCardiovascular: tachycardia, hypertension, chest painPsychiatric: acute psychosis, confusion, self-harm ideationRespiratory: depressed breathing in overdose scenariosVariable purity and dosing in street preparations greatly increase the likelihood of accidental overdose, with documented cases of collapse and extreme sedation requiring urgent medical intervention.
Legal Status and Regulatory Control
To date, 5F-MN24 has been subject to emergency scheduling or analogue controls in many jurisdictions:United States: Treated as a Schedule I analogue of existing synthetic cannabinoidsUnited Kingdom: Controlled under the Psychoactive Substances Act (PSA)European Union: Many member states have enacted rapid bans or temporary controlsAustralia & Canada: Included in broad synthetic cannabinoid prohibitionsUnauthorized manufacture, distribution, or possession can result in criminal charges, although clandestine chemists often modify structures to stay ahead of regulations.
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