Gamma-hydroxybutyrate (GHB)

Is a central nervous system (CNS) depressant that occurs naturally in the human brain in small amounts. It has both medical and recreational applications, leading to a controversial legal status in many countries. Medically, GHB is used to treat narcolepsy and alcohol dependence, but it is also misused as a recreational drug and known for its involvement in cases of drug-facilitated sexual assault due to its sedative effects.

Chemical and Pharmacological Profile

GHB is structurally similar to gamma-aminobutyric acid (GABA), a key inhibitory neurotransmitter. It acts on GABA-B and specific GHB receptors, leading to effects such as:
Sedation Euphoria Reduced anxiety Disinhibition Drowsiness or sleep induction At low doses, GHB can induce feelings of relaxation and mild euphoria. At higher doses, it causes deep sedation, confusion, muscle relaxation, and potentially unconsciousness.
Medical Uses

In its pharmaceutical form, sodium oxybate (a sodium salt of GHB) is legally prescribed for:
Narcolepsy with cataplexy (under brand names like Xyrem or Xywav) Off-label treatment of alcohol withdrawal or dependency in some European countries Medical use is tightly regulated due to its narrow therapeutic window and high abuse potential.
Recreational Use and Effects

GHB is often misused recreationally for its:
Euphoric and sociability-enhancing effects Muscle-relaxing properties (sometimes by bodybuilders) Aphrodisiac qualities (sometimes called “liquid ecstasy,” although unrelated to MDMA) Street names include G, Georgia Home Boy, Liquid X, or Fantasy. It is usually sold as a clear, salty liquid, sometimes as a powder.
Short-term effects include
Mild euphoria Relaxation and lowered inhibitions Drowsiness or confusion Slurred speech Nausea and dizziness High doses or combination with other depressants (e.g., alcohol, benzodiazepines) can result in: Seizures Loss of consciousness Coma Respiratory depression Death Due to its fast onset and colorless nature, GHB has been used in drug-facilitated sexual assaults, which has intensified regulatory controls.
Legal Status
Region Legal Classification United States Schedule I (non-medical use) & Schedule III (medical use – sodium oxybate only) United Kingdom Class C drug (possession and supply are criminal offenses) Australia Schedule 9 (Prohibited Substance) European Union Varies by country – generally controlled but prescribed in some nations Canada Schedule I controlled substance – unauthorized use is illegal In most countries, recreational possession and distribution are criminal offenses, though limited medical
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