FAB-144

Is a synthetic cannabinoid belonging to the family of indazole-based synthetic cannabinoids, structurally related to AB-FUBINACA and other substances designed to interact with the endocannabinoid system. Initially synthesized for research purposes, FAB-144 was later identified in designer drug products, often marketed as "legal highs" or sold as herbal incense mixtures under names like “Spice” or “K2.”

It is considered part of the wider class of novel psychoactive substances (NPS), which continue to pose significant challenges to forensic toxicologists and public health authorities due to their evolving chemistry and severe adverse effects.

Chemical Identity and Structure

IUPAC Name: N-[[1-[(4-fluorophenyl)methyl]indazole-3-carbonyl]amino]-3,3-dimethylbutanamide
Molecular Formula: C₂₀H₂₃FN₄O₂ Molecular Weight: 370.42 g/mol Chemical Class: Synthetic cannabinoid, indazole-based Physical Appearance: White or off-white crystalline powder FAB-144 is structurally similar to AB-FUBINACA, with slight alterations in the amide group, contributing to changes in its receptor binding profile and potentially increasing potency at CB₁ receptors.
Pharmacology and Mechanism of Action

Like other synthetic cannabinoids, FAB-144 is a full agonist at CB₁ and CB₂ receptors, unlike Δ9-THC (a partial agonist). This means it activates cannabinoid receptors more strongly and completely, often resulting in more intense psychoactive and physiological effects.
Reported pharmacological effects include: Rapid onset of euphoria Altered sensory and temporal perception Motor impairment Sedation or dissociation Anxiety or panic reactions at higher doses
Toxicity and Adverse Effects

Use of FAB-144, especially in uncontrolled or unregulated contexts, is associated with severe and potentially life-threatening outcomes. Documented or suspected toxic effects include:
Acute psychosis and agitation Tachycardia, hypertension Nausea, vomiting, abdominal cramps Respiratory depression Seizures Kidney or liver dysfunction Loss of consciousness or coma The narrow margin between psychoactive and toxic doses makes synthetic cannabinoids like FAB-144 particularly dangerous, especially when sold in pre-mixed or unlabeled products.
Legal and Regulatory Status

FAB-144 has been regulated in many countries under synthetic cannabinoid laws or emergency scheduling frameworks:
Controlled in the United States (often via analogue provisions of Schedule I) Listed as a controlled substance in the UK, EU, China, and Japan Monitored by the UNODC Early Warning Advisory on NPS Its distribution, possession, or sale is illegal in most jurisdictions without explicit research exemption.
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