MAPB (1-(benzofuran-5-yl)-N-methylpropan-2-amine)

Is a synthetic entactogen and stimulant, structurally related to the more well-known compound MDMA (commonly known as ecstasy). Initially studied for its psychoactive effects, MAPB has emerged in the designer drug and research chemical markets as an alternative to established empathogenic substances.

Due to its chemical resemblance to benzofuran-based compounds, it is often included in discussions on novel psychoactive substances (NPS) and is monitored by toxicologists and forensic experts due to its potential health risks and abuse potential.

Chemical Identity and Structure

IUPAC Name: 1-(benzofuran-5-yl)-N-methylpropan-2-amine
Common Name: MAPB Chemical Class: Benzofuran derivative / Entactogen Molecular Formula: C₁₂H₁₇NO Molecular Weight: 191.27 g/mol CAS Number: 1354631-34-9 Physical Appearance: Off-white to beige crystalline powder MAPB is closely related to 6-APB and 5-APB, which have been studied for their serotonergic and stimulant properties. It shares a core structural motif with these compounds: a benzofuran ring fused to a substituted amphetamine skeleton.
Pharmacology and Mechanism of Action

MAPB is thought to function as a releasing agent for serotonin (5-HT), dopamine (DA), and norepinephrine (NE). Like MDMA, it likely acts on monoamine transporters, particularly SERT, DAT, and NET, causing a rapid release of neurotransmitters into the synaptic cleft.
Expected effects may include: Enhanced mood and euphoria Increased sociability and empathy (entactogenic effects) Mild to moderate stimulation Heightened sensory perception However, unlike MDMA, MAPB's effects are less well studied in humans, and anecdotal reports suggest it may be less stimulating but longer-lasting.
Potential Risks and Side Effects

While MAPB is sometimes marketed as a "safer" or "legal" alternative to MDMA, it carries a range of serious health risks, particularly when used recreationally or at high doses.
Possible adverse effects include: Elevated blood pressure and heart rate Hyperthermia (overheating) Anxiety, confusion, or agitation Serotonin syndrome (especially in combination with SSRIs) Neurotoxicity with repeated or high-dose use Post-use depression or fatigue ("comedown") Because MAPB affects serotonin systems, it also shares risks associated with MDMA, including potential neurotoxic effects and emotional disturbances after repeated use.
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