Buy AB-FUBINACA is a powerful synthetic cannabinoid
First developed by Pfizer Inc. in 2009 as part of pharmaceutical research into cannabinoid receptor agonists. Though initially designed for potential therapeutic applications, AB-FUBINACA was never approved for medical use. Instead, it appeared on the illicit market in synthetic cannabis products, where it rapidly became associated with severe intoxication, overdose cases, and fatalities.
Chemical Identity and StructureIUPAC Name: N-[(1S)-1-(aminocarbonyl)-2-methylpropyl]-1-[(4-fluorophenyl)methyl]-1H-indazole-3-carboxamideCommon Name: AB-FUBINACAMolecular Formula: C₂₀H₂₁FN₄O₂Molecular Weight: 368.41 g/molChemical Class: Indazole-based synthetic cannabinoidPhysical Appearance: White to off-white crystalline powderCAS Number: 1185282-01-2Structurally, AB-FUBINACA is an indazole-3-carboxamide derivative with a 4-fluorobenzyl substituent, contributing to its strong affinity for cannabinoid receptors, especially CB₁.
Pharmacology and Mechanism of ActionAB-FUBINACA acts as a full agonist at CB₁ and CB₂ receptors, part of the endocannabinoid system. This is in contrast to THC (from natural cannabis), which is only a partial agonist. As a result, AB-FUBINACA can cause much more intense and unpredictable physiological effects.Key properties:CB₁ receptor affinity: Sub-nanomolar range (extremely high potency)Onset: Rapid – often within minutesDuration: Short but intense psychoactive episodePotency: Estimated to be 50–100 times stronger than THCCommon effects reported by users:Strong sedation and confusionVisual and auditory hallucinationsEuphoria or anxietyLoss of motor coordinationCatatonic states or unconsciousnessDue to its extreme potency, even small doses (in micrograms) may trigger severe reactions or overdose.Toxicological Effects and Health HazardsAB-FUBINACA has been implicated in numerous emergency room visits and fatalities, particularly in cases where it was unknowingly consumed as part of “herbal incense” or fake cannabis products.Documented adverse effects include:Seizures and convulsionsCardiovascular toxicity (hypertension, arrhythmias)Respiratory depressionDelirium, psychosis, or aggressionMuscle breakdown (rhabdomyolysis)Kidney injury or acute renal failureDeath, often linked to cardiac arrest or multi-organ failureIn 2014, a major outbreak of poisonings in the U.S. was linked to synthetic blends containing AB-FUBINACA, drawing national attention to the dangers of synthetic cannabinoids.
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