A-PHP (alpha-pyrrolidinohexanophenone)
Is a synthetic stimulant that belongs to the cathinone class of compounds, structurally related to alpha-PVP and MDPV. Originally synthesized for research and forensic purposes, A-PHP has gained notoriety as a designer drug, often found in the illicit stimulant market. Known for its potent psychoactive effects, it is used primarily for its euphoric and stimulant properties, though it carries serious health risks.
Chemical Identity and StructureIUPAC Name: 1-phenyl-2-pyrrolidin-1-ylhexan-1-oneCommon Name: A-PHPChemical Class: Synthetic cathinone / PyrrolidinophenoneMolecular Formula: C₁₆H₂₃NOMolecular Weight: 245.36 g/molCAS Number: 19134-50-0Physical Form: Fine white or off-white crystalline powderA-PHP is a homolog of alpha-PVP with a longer alkyl side chain, enhancing its lipid solubility and, in some cases, modifying its potency and duration of action.
Mechanism of Action and PharmacodynamicsA-PHP acts primarily as a central nervous system (CNS) stimulant, similar to other synthetic cathinones. It functions by inhibiting the reuptake of norepinephrine and dopamine, leading to elevated concentrations of these neurotransmitters in the brain.Key effects include:Increased alertness and energyEnhanced focus and motivationEuphoria and mood elevationReduced appetiteHowever, these effects are often followed by:Irritability or anxietyInsomniaTachycardiaCompulsive redosingA-PHP is often consumed via insufflation (snorting), oral ingestion, or vaporization, with vaporizing known to cause rapid and intense effects, sometimes leading to addiction-like behavior.
Toxicology and Health RisksDespite its popularity in certain online and street-level markets, A-PHP carries significant adverse health risks. Because it is not clinically approved, its safety profile remains poorly studied.Reported side effects and risks:Cardiovascular issues: hypertension, arrhythmiasNeurological effects: tremors, seizures, paranoiaPsychiatric effects: hallucinations, panic, psychosisRisk of dependence and compulsive usePost-use “crash” symptoms: depression, fatigue, agitationAdditionally, inhaling or vaporizing A-PHP may result in lung irritation, chemical burns, and increased systemic toxicity.
Legal ClassificationAs part of ongoing regulation of synthetic stimulants, many countries have placed A-PHP under controlled substance laws:United States: Treated as an analogue of alpha-PVP (Schedule I)Germany: Listed under the NpSG (New Psychoactive Substances Act)UK: Class B under the Misuse of Drugs ActSweden, Australia, Japan: Explicitly bannedDue to its structural similarity to banned substances, possession or sale is often treated as a criminal offense.
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