4-MeO-PCP (4-methoxyphencyclidine)

Is a synthetic arylcyclohexylamine dissociative, structurally derived from phencyclidine (PCP). First synthesized in the 1960s for psychotomimetic research, it has reemerged in the novel psychoactive substance (NPS) market as a “research chemical” and is often encountered in crystalline form. Its para-methoxy substitution on the phenyl ring modifies receptor interactions, leading to potent dissociative and hallucinogenic effects alongside significant safety concerns.

Chemical Identity and Structure

IUPAC Name: 4-methoxy-1-(1-phenylcyclohexyl)piperidine
Common Name: 4-MeO-PCP Chemical Class: Arylcyclohexylamine dissociative Molecular Formula: C₁₇H₂₅NO Molecular Weight: 267.38 g/mol Physical Form: Fine white to off-white crystalline solid 4-MeO-PCP features a methoxy group at the para position of the phenyl ring attached to the cyclohexyl piperidine core. This substitution increases lipophilicity and may alter binding affinity at NMDA receptors compared to PCP.
Pharmacology and Mechanism of Action

4-MeO-PCP acts primarily as a non-competitive antagonist at the N-methyl-D-aspartate (NMDA) receptor:
NMDA blockade: Disrupts glutamatergic neurotransmission, producing dissociation, anesthesia, and hallucinatory states Secondary targets: May interact with dopamine and sigma receptors, contributing to stimulant and psychotomimetic effects Typical effects onset within 15–30 minutes of oral ingestion or 5–10 minutes when insufflated, peaking around 1–2 hours, with a total duration of 4–6 hours.
Toxicity and Adverse Effects

4-MeO-PCP carries a narrow safety margin and poses serious risks, including:
Dissociative toxicity: profound detachment, confusion, and amnesia Psychiatric: anxiety, paranoia, acute psychosis, suicidal ideation Neurological: ataxia, tremors, nystagmus, seizures in overdose Cardiovascular: tachycardia, hypertension, arrhythmias Respiratory: depression at high doses, risk of respiratory arrest Because users often misjudge dose and purity, accidental overdose and dangerous “k-hole” experiences are common. Long-term or high-frequency use may precipitate persistent cognitive deficits or mood disturbances.
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