AB-FUBINACA is a powerful synthetic cannabinoid

First developed by Pfizer Inc. in 2009 as part of pharmaceutical research into cannabinoid receptor agonists. Though initially designed for potential therapeutic applications, AB-FUBINACA was never approved for medical use. Instead, it appeared on the illicit market in synthetic cannabis products, where it rapidly became associated with severe intoxication, overdose cases, and fatalities.

Chemical Identity and Structure

IUPAC Name: N-[(1S)-1-(aminocarbonyl)-2-methylpropyl]-1-[(4-fluorophenyl)methyl]-1H-indazole-3-carboxamide
Common Name: AB-FUBINACA Molecular Formula: C₂₀H₂₁FN₄O₂ Molecular Weight: 368.41 g/mol Chemical Class: Indazole-based synthetic cannabinoid Physical Appearance: White to off-white crystalline powder CAS Number: 1185282-01-2 Structurally, AB-FUBINACA is an indazole-3-carboxamide derivative with a 4-fluorobenzyl substituent, contributing to its strong affinity for cannabinoid receptors, especially CB₁.
Pharmacology and Mechanism of Action

AB-FUBINACA acts as a full agonist at CB₁ and CB₂ receptors, part of the endocannabinoid system. This is in contrast to THC (from natural cannabis), which is only a partial agonist. As a result, AB-FUBINACA can cause much more intense and unpredictable physiological effects.
Key properties: CB₁ receptor affinity: Sub-nanomolar range (extremely high potency) Onset: Rapid – often within minutes Duration: Short but intense psychoactive episode Potency: Estimated to be 50–100 times stronger than THC Common effects reported by users: Strong sedation and confusion Visual and auditory hallucinations Euphoria or anxiety Loss of motor coordination Catatonic states or unconsciousness Due to its extreme potency, even small doses (in micrograms) may trigger severe reactions or overdose.
Toxicological Effects and Health Hazards

AB-FUBINACA has been implicated in numerous emergency room visits and fatalities, particularly in cases where it was unknowingly consumed as part of “herbal incense” or fake cannabis products.
Documented adverse effects include: Seizures and convulsions Cardiovascular toxicity (hypertension, arrhythmias) Respiratory depression Delirium, psychosis, or aggression Muscle breakdown (rhabdomyolysis) Kidney injury or acute renal failure Death, often linked to cardiac arrest or multi-organ failure In 2014, a major outbreak of poisonings in the U.S. was linked to synthetic blends containing AB-FUBINACA, drawing national attention to the dangers of synthetic cannabinoids.
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