AB-CHMINACA

Is a highly potent synthetic cannabinoid originally synthesized by Pfizer for pharmaceutical research. It belongs to the indazole-based cannabinoid class and has since entered the novel psychoactive substance (NPS) market, where it has been associated with numerous toxicity cases, fatalities, and mass intoxication events.

Chemical Identity and Structure

IUPAC Name: N-[1-amino-3-methyl-1-oxobutan-2-yl]-1-(cyclohexylmethyl)-1H-indazole-3-carboxamide
Common Name: AB-CHMINACA Chemical Class: Indazole-based synthetic cannabinoid Molecular Formula: C₂₀H₂₈N₄O₂ Molecular Weight: 356.46 g/mol Appearance: White to off-white powder or crystal Structural Highlights: AB-CHMINACA features a cyclohexylmethyl group on the indazole core, a modification that enhances lipid solubility, CB₁ receptor binding, and central nervous system penetration.
Pharmacology and Mechanism of Action

AB-CHMINACA is a full agonist at the CB₁ and CB₂ cannabinoid receptors, unlike THC, which is only a partial agonist. This results in:
Extremely strong psychoactive effects High risk of overdose and adverse reactions Short duration but intense intoxication Effects may include: Euphoria, altered perception Catatonia or sedation Anxiety, confusion, paranoia Rapid tolerance and dependence development
Toxicity and Adverse Effects
AB-CHMINACA has been linked to severe and life-threatening toxic effects, often at very low doses:
Reported Adverse Effects: Seizures Cardiac arrhythmias Respiratory depression Hyperthermia Loss of consciousness Aggressive or violent behavior Renal failure and rhabdomyolysis A narrow therapeutic index means that tiny variations in dose can cause severe toxicity. In 2015, AB-CHMINACA was linked to over 30 deaths and hundreds of ER admissions in the United States alone.
Legal Status

United States: Schedule I controlled substance
European Union: Controlled under various national and EU-wide bans Australia & New Zealand: Schedule I / banned Asia (e.g., Japan, Indonesia, Malaysia): Prohibited under narcotic laws Despite international controls, AB-CHMINACA analogues and mislabelled products continue to circulate.
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