A-PVT Powder (chemical name: alpha-pyrrolidinopentiothiophenone)
Is a lesser-known but highly potent synthetic stimulant belonging to the thiophenedione and pyrrolidine class of cathinones. Structurally related to compounds like alpha-PVP ("Flakka"), A-PVT has been sold online and in underground markets as a research chemical or "legal high". Though its use is not widespread, it carries significant health risks and is often included in new psychoactive substance (NPS) alerts due to its psychoactive potency and unpredictable effects.
Chemical Overview
A-PVT is chemically categorized as a thiophene analogue of alpha-PVP, replacing the phenyl ring with a thiophene ring. It typically appears in the form of a white, off-white, or yellowish powder, and is usually consumed orally, nasally, or sometimes vaporized. Its pharmacological profile includes powerful stimulant effects and dopaminergic activity, which can lead to high abuse potential. A-PVT has no recognized medical use, and very limited formal research exists on its effects in humans.
Mechanism of Action
Like other pyrrolidine-based cathinones, A-PVT acts primarily as a dopamine and norepinephrine reuptake inhibitor (DNRI). This increases extracellular levels of these neurotransmitters, resulting in heightened alertness, energy, and euphoria. However, this same mechanism also leads to cardiovascular strain, agitation, and possible psychosis at higher doses, particularly in uncontrolled settings or when combined with other stimulants.
Risks and Health Concerns
Due to its potency and similarity to alpha-PVP, A-PVT presents serious health risks:
High addiction potential, especially with repeated dosing
Risk of overdose, due to the narrow margin between active and toxic doses
Neurological effects, including confusion, hallucinations, and paranoia
Cardiovascular stress, increasing risk for heart attack or stroke
Behavioral unpredictability, including aggression and psychotic behavior
Long-term unknowns, as no clinical trials or safety data are available
Many reported incidents involve hospitalization or psychiatric emergencies following A-PVT use, particularly among users expecting a weaker stimulant.
Legal Status
Though not as globally recognized as alpha-PVP, A-PVT has gained the attention of drug enforcement bodies:
United States: Likely treated as an analogue of alpha-PVP under the Federal Analogue Act, making possession and distribution illegal
United Kingdom: Controlled under the Psychoactive Substances Act (2016)
European Union: Banned or under review in multiple EU countries
Australia and Canada: Controlled under analogue drug laws
In most jurisdictions, possession, sale, or distribution of A-PVT for human consumption is illegal, even if not listed by name, due to its structural similarity to banned substances.
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