6-APDB Powder (chemical name: 6-(2-aminopropyl)-2,3-dihydrobenzofuran)
Is a synthetic entactogenic and stimulant compound developed in the 1990s. It belongs to a class of chemicals known as benzofurans, and is structurally and functionally similar to MDMA (ecstasy) and MDA. Though never approved for medical use, 6-APDB has surfaced in online research chemical markets and is used recreationally for its mood-enhancing and empathetic effects. Despite its resemblance to more well-known drugs, the safety profile of 6-APDB is not well understood, and its use is associated with legal and health risks.
Chemical Overview
6-APDB is part of the APDB family (along with 5-APDB), and is sometimes marketed as a “legal MDMA alternative”. It typically appears as a fine crystalline powder, taken either orally, nasally, or in capsules. Users often seek its empathogenic, euphoric, and sensory-enhancing effects. However, the compound lacks proper pharmacological evaluation and has never been clinically tested or approved for human consumption.
Mechanism of Action
6-APDB is believed to act as a serotonin, dopamine, and norepinephrine releasing agent (SDNRA). This means it increases the levels of these neurotransmitters in the brain, leading to feelings of well-being, emotional closeness, and stimulation. Its pharmacology mimics MDMA, but some reports suggest it may have a longer duration and slightly milder stimulant effects, though results vary widely between users.
Health Risks and Concerns
Despite being perceived as a "softer" alternative to MDMA, 6-APDB carries many of the same risks, including:
Neurotoxicity from excessive serotonin release
Serotonin syndrome if combined with other serotonergic drugs
Overstimulation of the cardiovascular system (racing heart, high blood pressure)
Dehydration or hyperthermia, especially in party environments
Unknown long-term effects due to lack of human trials
Potential for psychological dependence
Use is particularly risky when dosing is inaccurate, which is common with unregulated powder forms.
Legal Status
The legal status of 6-APDB varies but is becoming more restricted:
United States: Not scheduled by name, but may be considered illegal under the Federal Analogue Act
United Kingdom: Likely covered by the Psychoactive Substances Act 2016, making sale and possession for human consumption illegal
European Union: Several member states have banned or are reviewing its legal status
Canada & Australia: Treated as an analogue of MDMA, making it controlled or illegal
In many jurisdictions, any substance with MDMA-like effects is regulated regardless of its specific name.
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