5F-SDB005 is a synthetic cannabinoid

That falls under the class of indazole-based cannabinoid receptor agonists, structurally and pharmacologically related to compounds like 5F-PB-22 and AB-FUBINACA. Originally developed for scientific studies on the endocannabinoid system, this compound has found its way into the illicit designer drug market, typically marketed as a “legal high” or a “herbal incense” additive.

As with other 5F-substituted cannabinoids, 5F-SDB005 is associated with strong psychoactive effects, low-dose potency, and a narrow safety margin, raising significant public health concerns.

Chemical Identity and Structure

IUPAC Name: N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-(5-fluoropentyl)-1H-indazole-3-carboxamide
Common Name: 5F-SDB005 Chemical Class: Indazole-based synthetic cannabinoid Molecular Formula: C₁₈H₂₅FN₄O₂ Molecular Weight: 348.42 g/mol CAS Number: Not formally registered in all databases Physical Appearance: White to off-white crystalline powder The structure of 5F-SDB005 includes a fluorinated pentyl chain, a carboxamide linkage, and a bulky t-butyl amino acid derivative, contributing to its high lipophilicity and receptor affinity.
Pharmacology and Mechanism of Action

5F-SDB005 functions as a full agonist at CB₁ and CB₂ cannabinoid receptors, showing significantly higher potency than Δ⁹-THC (the primary psychoactive compound in cannabis). Due to this strong binding, the psychoactive effects of 5F-SDB005 can be rapid, intense, and unpredictable.
Reported effects may include: Intense euphoria or altered mental state Distorted time perception Elevated mood followed by anxiety or paranoia Disorientation and confusion Increased heart rate and blood pressure While the mechanism of action is similar to other cannabinoids, the intensity and toxicity of synthetic analogs like 5F-SDB005 far exceed natural cannabinoids.
Adverse Effects and Health Risks

The use of 5F-SDB005 has been associated with a number of acute and serious side effects, especially when used unknowingly in herbal blends or when overdosed:
Neurological: seizures, confusion, agitation, hallucinations Cardiovascular: tachycardia, hypertension, chest pain Gastrointestinal: nausea, vomiting Renal and hepatic: acute organ injury in rare cases Respiratory: difficulty breathing in overdose scenarios Due to its full agonist action at CB₁ receptors, even low doses may result in severe toxicological responses, particularly in naive users.
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