GBL (Gamma-Butyrolactone)

sold as "Wheel Cleaner" or "Alloy Cleaner" is a chemical solvent commonly used in industrial and automotive cleaning. However, it is also known as a precursor to GHB (Gamma-Hydroxybutyrate), a powerful central nervous system depressant. GBL is readily converted to GHB in the body, making it a substance of abuse and subject to increasing legal control.

Chemical Identity

Full Name: Gamma-Butyrolactone
Common Name: GBL, 1,4-Butanolide Molecular Formula: C₄H₆O₂ Molecular Weight: 86.09 g/mol Chemical Class: Lactone (cyclic ester) Physical Form: Colorless, oily liquid with a faint sweet odor Solubility: Miscible with water and organic solvents
Legitimate Uses

GBL has numerous industrial and commercial applications, including:
Wheel and rim cleaner Paint stripper Nail polish remover Solvent in chemical manufacturing Intermediate in polymer production When sold as a “wheel cleaner”, GBL is often marketed as non-toxic and biodegradable, but in reality, its primary use in some markets is covert recreational drug synthesis or consumption.
Pharmacology (When Ingested)

Once ingested, GBL is rapidly converted to GHB by enzymes in the blood and liver:
Mechanism: GBL → GHB → Activation of GABA-B receptors Effects: Sedation Euphoria Anxiolysis (anti-anxiety effect) Muscle relaxation Increased sociability Effects begin within 10–30 minutes and may last 2–4 hours.
Toxicity and Risks

Although used industrially, GBL is dangerous when ingested:
Health Risks: Nausea and vomiting Loss of consciousness Respiratory depression Seizures Coma and death (especially when combined with alcohol or other depressants) Addiction Potential: GBL has high abuse potential Severe withdrawal symptoms: anxiety, insomnia, tremors, hallucinations, and delirium Physical dependence can develop quickly (within days of use)
Legal Status

Many countries have imposed strict controls on GBL due to its role as a GHB precursor:
Region Legal Status USA Listed as a List I chemical; regulated under the Controlled Substances Act UK Class C drug (if intended for human consumption) EU Controlled as a drug precursor in many countries Australia Schedule 9 poison Canada Schedule VI precursor substance Sale as a "wheel cleaner" is often a loophole used by illicit distributors to evade regulation.
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