Carfentanil is an extremely potent synthetic opioid, primarily used in veterinary medicine to sedate large animals such as elephants and rhinoceroses. It is estimated to be 10,000 times more potent than morphine and 100 times more potent than fentanyl, making it one of the most powerful opioid substances known to science.
In powder form,
Carfentanil is particularly dangerous due to its high absorption rate through the skin or inhalation, and even a few micrograms can be lethal to humans. It is not approved for human use in any country and is classified as a Schedule I controlled substance in many jurisdictions.
Chemical Identity
IUPAC Name: methyl 1-(2-phenylethyl)-4-(N-propanoylanilino)piperidine-4-carboxylate
Molecular Formula: C₂₄H₃₀N₂O₃
Molar Mass: 394.51 g/mol
Chemical Class: Synthetic opioid (4-anilidopiperidine class)
Carfentanil is structurally related to fentanyl, but with a far greater binding affinity to the μ-opioid receptor, which accounts for its extreme potency.
Mechanism of Action
Carfentanil binds to mu-opioid receptors (MOR) in the brain and spinal cord, blocking pain signals and producing powerful sedation and euphoria. Due to its high lipid solubility, it rapidly crosses the blood-brain barrier, resulting in near-instantaneous respiratory depression, even in microgram doses.
Risks and Toxicity
Carfentanil powder poses extreme risks, even in trace quantities. Accidental exposure can cause:
Immediate respiratory arrest
Loss of consciousness
Bradycardia (dangerously slow heart rate)
Death within minutes without intervention
The substance is so potent that traditional opioid overdose treatments like naloxone (Narcan) may require multiple, high-dose administrations to reverse its effects.
Legal Classification
Carfentanil is classified as a Schedule I drug in the U.S. and banned in many other countries due to:
No accepted medical use in humans
High abuse potential
Extreme danger of overdose and death
Its distribution, possession, or manufacturing without specific high-level regulatory approval is strictly illegal.
Veterinary Use (Highly Regulated)
In veterinary medicine, Carfentanil is used exclusively by trained wildlife professionals and veterinarians in large animal immobilization protocols. Even in that context, its use is being phased out due to safety concerns.
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