Amphetamine is a potent central nervous system (CNS) stimulant that affects chemicals in the brain and nerves contributing to hyperactivity and impulse control. It has a long history of medical usage for specific conditions such as Attention Deficit Hyperactivity Disorder (ADHD) and narcolepsy, but also holds a high potential for abuse and addiction, especially in powder form, which is more potent and prone to misuse.

Chemical Identity

IUPAC Name: 1-phenylpropan-2-amine

Molecular Formula: C₉H₁₃N

Molar Mass: 135.21 g/mol

Chemical Class: Phenethylamine and substituted amphetamine

Amphetamine exists in two enantiomeric forms:

levoamphetamine and dextroamphetamine, the latter being more potent in CNS stimulation.

Most pharmaceutical amphetamines are found as salts (like amphetamine sulfate) rather than raw base powder.

Mechanism of Action

Amphetamine works primarily by increasing the levels of dopamine, norepinephrine, and serotonin in the synaptic cleft of neurons.

It does this by:

Stimulating release of monoamines from presynaptic neurons

Blocking reuptake transporters

Inhibiting monoamine oxidase (in higher doses)

The result is heightened alertness, improved concentration, and reduced fatigue, which is why it’s medically useful in treating disorders like ADHD and sleep disorders such as narcolepsy.

Approved Medical Uses

When used under prescription and in regulated doses, amphetamine-based medications can treat:

ADHD (Attention Deficit Hyperactivity Disorder)

Narcolepsy

Occasionally used off-label for treatment-resistant depression or obesity

Common brand names include Adderall, Dexedrine, and Evekeo, which are formulated with controlled-release mechanisms to reduce abuse potential.

Side Effects and Health Risks

Despite its medical value, amphetamine has a high potential for abuse, particularly when used in unregulated, powdered form.

Common side effects include:
Insomnia Increased heart rate Elevated blood pressure Anxiety or agitation Appetite suppression Severe or chronic misuse can lead to: Cardiovascular issues (e.g., arrhythmia, stroke) Paranoia or psychosis (amphetamine-induced) Dependence and withdrawal symptoms Neurological damage with long-term abuse
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