4-Fluoroamphetamine (4-FA), also known as para-fluoroamphetamine,

Is a synthetic stimulant that gained popularity in the 2010s as a research chemical and "legal high". Belonging to the amphetamine class, 4-FA shares structural similarities with amphetamine and MDMA, offering a mix of stimulant and empathogenic effects. It has been used recreationally for enhancing mood, focus, and sociability, but its use is associated with health risks and increasing legal restrictions. While users initially viewed it as a safer alternative to MDMA or amphetamine, medical reports and incidents of toxicity have since led to greater scrutiny.

Chemical Overview

4-FA is a substituted amphetamine in which a fluorine atom is placed at the para (4th) position on the phenyl ring. It usually appears in crystalline or powdered form, and is consumed orally, intranasally, or occasionally vaporized. Its action combines both dopaminergic stimulation (similar to amphetamine) and serotonin release (similar to MDMA), giving it a dual profile that some users describe as “a mild MDMA with focus.”

Mechanism of Action

4-FA functions as a monoamine releasing agent, meaning it causes the release of:
Dopamine (linked to motivation, reward) Norepinephrine (linked to alertness and energy) Serotonin (linked to mood and empathy) This blend results in both stimulant and entactogenic effects, though serotonin depletion after use can cause a harsh comedown. Unlike traditional amphetamines, 4-FA’s serotonin activity sets it apart and increases risk for serotonin syndrome at high doses.
Legal Status

The growing evidence of harm has led many countries to ban 4-FA:
United States: Not federally scheduled by name but may fall under the Federal Analogue Act Netherlands: Initially legal, but banned in 2017 due to medical emergencies United Kingdom: Controlled under the Psychoactive Substances Act 2016 Germany & EU: Controlled as a new psychoactive substance Australia & Canada: Generally illegal under analogue or psychoactive drug laws Most countries now treat 4-FA as a controlled substance, prohibiting its sale and possession.
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