6-APDB Powder (chemical name: 6-(2-aminopropyl)-2,3-dihydrobenzofuran)
Is a synthetic entactogenic and stimulant compound developed in the 1990s. It belongs to a class of chemicals known as benzofurans, and is structurally and functionally similar to MDMA (ecstasy) and MDA. Though never approved for medical use, 6-APDB has surfaced in online research chemical markets and is used recreationally for its mood-enhancing and empathetic effects. Despite its resemblance to more well-known drugs, the safety profile of 6-APDB is not well understood, and its use is associated with legal and health risks.
Chemical Overview
6-APDB is part of the APDB family (along with 5-APDB), and is sometimes marketed as a “legal MDMA alternative”. It typically appears as a fine crystalline powder, taken either orally, nasally, or in capsules. Users often seek its empathogenic, euphoric, and sensory-enhancing effects. However, the compound lacks proper pharmacological evaluation and has never been clinically tested or approved for human consumption.
Mechanism of Action
6-APDB is believed to act as a serotonin, dopamine, and norepinephrine releasing agent (SDNRA). This means it increases the levels of these neurotransmitters in the brain, leading to feelings of well-being, emotional closeness, and stimulation. Its pharmacology mimics MDMA, but some reports suggest it may have a longer duration and slightly milder stimulant effects, though results vary widely between users.
Health Risks and ConcernsDespite being perceived as a "softer" alternative to MDMA, 6-APDB carries many of the same risks, including:Neurotoxicity from excessive serotonin releaseSerotonin syndrome if combined with other serotonergic drugsOverstimulation of the cardiovascular system (racing heart, high blood pressure)Dehydration or hyperthermia, especially in party environmentsUnknown long-term effects due to lack of human trialsPotential for psychological dependenceUse is particularly risky when dosing is inaccurate, which is common with unregulated powder forms.
Legal StatusThe legal status of 6-APDB varies but is becoming more restricted:United States: Not scheduled by name, but may be considered illegal under the Federal Analogue ActUnited Kingdom: Likely covered by the Psychoactive Substances Act 2016, making sale and possession for human consumption illegalEuropean Union: Several member states have banned or are reviewing its legal statusCanada & Australia: Treated as an analogue of MDMA, making it controlled or illegalIn many jurisdictions, any substance with MDMA-like effects is regulated regardless of its specific name.
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